Description
MG Medicals, Quality Assurance
CompositionDaratumumab
UsageMultiple Myeloma
MG Medicals, Briefing of Darzalex 400mg 1s
Uses of Darzalex 400mg 1sDarzalex as monotherapy is indicated for the treatment of adult patients with relapsed and refractory multiple myeloma, whose prior therapy included a proteasome inhibitor and an immunomodulatory agent and who have demonstrated disease progression on the last therapy
Darzalex 400mg 1s side reactionsInfusion reactions, neutropenia, thrombocytopenia, fatigue, nausea, diarrhea, constipation, vomiting, muscle spasms, arthralgia, back pain, pyrexia, chills, dizziness, insomnia, cough, dyspnea, peripheral edema, peripheral sensory neuropathy, upper respiratory tract infection.
How to take Darzalex 400mg 1sShould be administered by a healthcare professional, with immediate access to emergency equipment and appropriate medical support to manage infusion reactions if they occur.
How Darzalex 400mg 1s worksMonoclonal antibody that binds with high affinity to the CD38 molecule, which is highly expressed on the surface of multiple myeloma cells. The binding to CD38 is believed to induce rapid tumor cell death through programmed cell death, or apoptosis, and multiple immune-mediated mechanisms, including complement-dependent cytotoxicity, antibody-dependent cellular phagocytosis, and antibody-dependent cellular cytotoxicity.
MG Medicals, More Suggestion
Suggestion for Darzalex 400mg 1s
- If infusion anaphylactic reaction or life-threatening reaction (Grade 4) occurs, institute appropriate care.
- Severe infusion reactions reported in ~50% of all patients (most during the first infusion); may also occur with subsequent infusions.
- Nearly all reactions occurred during infusion or within 4 hr of completing infusion.
- Prior to the introduction of postinfusion medication in clinical trials, infusion reactions occurred up to 48 hr after infusion.
- Severe reactions have occurred, including bronchospasm, hypoxia, dyspnea, and hypertension.
- Signs and symptoms may include respiratory symptoms (eg, cough, wheezing, larynx, throat tightness and irritation), laryngeal edema, pulmonary edema, nasal congestion, and allergic rhinitis.
- Less common symptoms were hypotension, headache, rash, urticaria, pruritus, nausea, vomiting, and chills.
- Premedicate patients with antihistamines, antipyretics, and corticosteroids.
- Frequently monitor patients during the entire infusion.
- Permanently discontinue for life-threatening (grade 4) reactions.
- For grade 1, 2, or 3 reactions, reduce the infusion rate when restarting the infusion.
- To reduce the risk of delayed infusion reactions, administer oral corticosteroids to all patients the first and second day after all infusions.
- Patients with a history of obstructive pulmonary disorders may require additional postinfusion medications to manage respiratory complications.
- Consider prescribing short- and long-acting bronchodilators and inhaled corticosteroids for patients with obstructive pulmonary disorders.
- May increase neutropenia or thrombocytopenia induced by background therapy; monitor CBC counts periodically during treatment; monitor patients with neutropenia for signs of infection; dose delay may be required to allow recovery of neutrophils; no dose reduction is recommended, consider supportive care with growth factors or transfusions.
MG Medicals, Tips & Warnings
Alcohol
There is no significant data. Please contact your doctor.
Pregnancy
WEIGH RISKS VS BENEFITS
Although there have not been any studies in humans or animals with Darzalex and therefore it is not known how this medication can affect unborn babies, monoclonal antibodies such as Darzalex cross the placenta and may cause harm to an unborn baby.
Lactation
It is not known if Darzalex crosses into human milk.
Driving
There is no significant data. Please contact your doctor.
Kidney
There is no significant data. Please contact your doctor.
Liver
There is no significant data. Please contact your doctor.
MG Medicals, If miss a dose
If you miss an appointment to receive a dose of Darzalex, call your doctor as soon as possible to reschedule.
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